Blar i forfatter "Lucarelli, Philippe"

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    • Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production 

      Mohapatra, Soumya R; Sadik, Ahmed; Sharma, Suraj; Poschet, Gernot; Gegner, Hagen M; Lanz, Tobias V; Lucarelli, Philippe; Klingmüller, Ursula; Platten, Michael; Heiland, Ines; Opitz, Christiane A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-19)
      The liver is the central hub for processing and maintaining homeostatic levels of dietary nutrients especially essential amino acids such as tryptophan (Trp). Trp is required not only to sustain protein synthesis but also as a precursor for the production of NAD, neurotransmitters and immunosuppressive metabolites. In light of these roles of Trp and its metabolic products, maintaining homeostatic ...

    • Stroma-induced phenotypic plasticity offers phenotype-specific targeting to improve melanoma treatment 

      Seip, Kotryna; Jørgensen, Kjetil Nordbø; Haselager, Marco Vincent; Albrecht, Marco; Haugen, Mads Haugland; Egeland, Eivind Valen; Lucarelli, Philippe; Engebråten, Olav; Sauter, Thomas; Mælandsmo, Gunhild Mari; Prasmickaite, Lina (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-18)
      Cancer cells' phenotypic plasticity, promoted by stromal cells, contributes to intra-tumoral heterogeneity and affects response to therapy. We have disclosed an association between fibroblast-stimulated phenotype switching and resistance to the clinically used BRAF inhibitor (BRAFi) vemurafenib in malignant melanoma, revealing a challenge in targeting the fibroblast-induced phenotype. Here we compared ...